I work as a consultant urological surgeon with special interest in uro-oncology. I regularly perform major uro-oncological procedures utilising the modalities (robotic , laparoscopic and open surgery as appropriate) include radical nephrectomy, nephroureterectomy, nephron sparing surgery (partial nephrectomy), caval thrombus excision, radical prostatectomy, radical cystectomy with ileal diversion( including Intracorporeal), anterior pelvic exenteration, pelvic and retroperitoneal lymphadenectomy, neo-bladder reconstruction, penile cancer surgery ( glansectomy, partial , total amputation), Inguinal node dissection and testicular cancer surgery.
I have substantiated my laparoscopic uro-oncology experience by completing laparoscopy and minimally invasive fellowship under Prof. Stolzenburg at University of Leipzig, Germany.
I am performing Robotic surgery including radical prostatectomy robotic cystectomy and intracorporeal conduit, Robotic partial nephrectomy, RPLND, Nephroureterectomy , adrenelectomy , VVF repair and help gynaecologists during hysterectomy & sacrocolpopexy.
Infact, I performed the first intracorporeal complete Nephroureterectomy at Chennai ( both upper and lower end), first Robotic RPLND for testicular Ca, Robotic Boari flap for uretric reconstruction & Extra Peritoneal Robotic Prostatectomy and Robotic Cystectomy + Intracorporeal Conduit , Intra corporeal Augumentation cystoplasty , Extraperitoneal segmental excision of ureter at Apollo Chennai..
I perform the full range of urological surgeries ( core urology) such as TURP , TURBT , Ureteroscopy , penoscrotal surgery However my area of interest is urooncology.
My full experience since 2005 is available electronically. Prior to this, I have maintained a hand-written logbook.
Speciality And Areas Of Interest
Laser Prostatectomy
Laparoscopic Radical Prostatectomy
Pyeloplasty
Laparoscopic Nephrectomy
Percutaneous Nephrolithotomy (PCNL)
Andrology
Transurethral Resection Of Prostate (TURP)
Stone disease and Endourology
Work Experience
Senior Consultant Urological Surgeon, Uro Oncologist Apollo Hospitals ChennaiSept 18
Senior Consultant Urological Surgeon, Uro OncologistGleneagles Global Hospitals, Chennai Nov 17- August 18
Consultant Urological Surgeon, Uro Oncologist Apollo Hospitals, ChennaiJan 13 Nov 17
Consultant Urological Surgeon And Uro Oncologist Bradford Royal Infirmary Aug11 to Dec 12
Consultant Urological Surgeon And Uro Oncologist Glan Clwyd Hospital April 11 to July 11
Fellowship in Laparoscopy and Minimally Invasive Urology University of LeipzigJan 11 to March 11
Subspeciality in UroOncology and Laparoscopy Wirral University HospitalFeb 10 to Dec10
Subspeciality in UroOncology and LaparoscopyRoyal Liverpool Hospital May 09 to Jan 10
Awards and Achievements
AWARDS AND HONOURS
Best of BAUS – Poster no 90 , Manchester 2006
Brian Booth Research Prize - Rosemere Cancer Foundation, 2005
Best Poster award – Poster session 37 at EAU, 2005
Best Presentation prize - North West Trainee’s Research Meeting, 2004
Best young Scientist award -1993-94, State Medical Council for Science and Technology.
Gold medal in surgery -1993, SRMC, India.
Gold medal in anatomy -1990, SRMC, India.
Honours in Anatomy, Physiology and Biochemistry In the University and College examinations -1990.
Honours in Ophthalmology, Microbiology and Community Medicine In the University Examinations -1992.
GRANTS
Grant for fellowship from Prostate UK
Norman Gibbon Travelling Fellowship
Seedcorn funding by the research directorate of Lancashire Teaching Hospitals NHS Trust
Joint applicant with Dr A Hindley for Rosemere Cancer Foundation funding for my research project.
Research and Publications
RESEARCH EXPERIENCE:
Thesis Title
An analysis of hormone- or carcinogen-metabolising enzyme expression in human prostate in relation to susceptibility to adenocarcinoma and an epidemiological investigation of lifestyle risk factors
Sections of the work have been presented in AACR (2004, 2005, 2006), UKEMS (2004), BPG (2004, 2006), URS (2005), EEMS (2005) and EAU (2006).
I have published part of the work in Cancer Letters, Biophysical Journal, Prostate Cancer and Prostatic Diseases and Prostate
Thesis Projects
“Inter- and Intra - individual differences in the gene expression of phase I and phase II enzymes in the normal prostate”
To investigate whether a differential expression profile in phase I/II genes might explain zone susceptibility to CaP, we obtained tissue sets consisting of PZ and transition zone (TZ) of prostate. Levels of CYP1B1 and NAT1 were distinctly higher in PZ. Immunohistochemistry confirmed the presence of CYP1B1 and NAT1 in the prostate.
“Survey of the incidence of major ailments amongst female partners of men diagnosed with prostate cancer: a pilot study”
A questionnaire study into the risk of common cancers in female partners of CaP males in NorthWest England was conducted. Rates for breast, colorectal or lung cancer among female partners were similar to estimates. However, observed rates for breast or lung cancers among previous female partnerss were significantly (p ?0.001) elevated
“IR spectroscopy with multivariate analysis potentially facilitates the segregation of different types of prostate cell”
The IR spectral signature of PZ and TZ was obtained using Fourier- transform infrared (FTIR) micro-spectroscopy Following spectroscopic analysis, plotted clusters and their loadings curves highlighted marked spectral variation in the region containing DNA/RNA bands (?1,490-1,000 cm-1). TZ cells appeared to align more closely with CaP cells while exhibiting marked structural differences compared to PZ cells.
In conclusion, the prostate gland possesses the metabolic machinery to activate pro-carcinogens. It is likely that environmental and/or dietary factors play an important role in the aetiology of CaP.
PUBLICATIONS:
Published
Ragavan N, Dholakia K, Ramesh M, Stolzenburg JU. Extraperitoneal vs.transperitoneal robot-assisted laparoscopic radical prostatectomy-analysis ofperioperative outcomes, a single surgeon's experience. J Robot Surg. 2018 Jul 19.
Shah P, Ragavan N, Bhat S, Dholakiya K. Case report: Robot-assistedlaparoscopic excision of giant ganglioneuroma of the adrenal gland. J Robot Surg. 2017 Jul 26.
Primary Intrarenal Yolk Sac Tumour . N Ragavan, K Dholakia, S Annapurneswari. IJU 2017 ; 33;2; 167
Robot assisted Laparoscopic excision of Organ of Zuckerkandl . N Ragavan, NK Narayanan, Malavizhi Ramesh, YVC Reddy. J. Robotic surgery. 2016. Dec;10(4):373-374
Prostate Biopsy for elevated PSA – Indian Perspective .N. Ragavan IJMR June 2014
Feasibility of minimally invasive radical prostatectomy in prostate cancer patients with high prostate-specific antigen: feasibility and 1-year outcomes Do M, Ragavan N, Dietel A, Liatsikos E, Anderson C, McNeill A, Stolzenburg JU. Int J Urol. 2012 Oct;19(10):923-7.