• Among the first rheumatologists in India to use Biologic agents for a variety of rheumatological disorders including Rheumatoid Arthritis, Inflammatory Spondylitis & Ankylosing Spondylitis
• Involved in advanced clinical research of new molecules / Biological agents in Rheumatoid Arthritis, Ankylosing Spondylitis and SLE (lupus).
• Member of the team involved in the IRA guidelines for Rheumatoid Arthritis treatment and regular contributor to CMEs, lectures and education of other doctors in the field of modern medicine, rheumatology, spondylitis and arthritis, lupus and other connective tissue diseases.
• Continues to be on the cutting edge of clinical medicine by interacting with specialists from all over the world in advisory boards, meetings and conferences.
• Involved in teaching of medical Postgraduate students at Indraprastha Apollo hospitals, New Delhi.

• A. Journal of Rheumatology (Intl.) Journal of Indian Rheumatology Association Apollo Medicine
• Complement and cell mediated cytotoxicity by antiendothelial cell antibodies in Takayasu’s arteritis. Authors: Naresh Tripathi, Sundeep Kumar Upadhyaya, Nakul Sinha, Sonia Nityanand. Journal of Rheumatology, 2001 April; 28(4):805-8.
• Methotrexate in Seronegative Spondyloarthropathy; results of a double-blind placebo
• controlled drug trial. Authors: Sundeep K Upadhyaya, Amita Aggarwal, Ram Nath Misra.  Journal of Indian Rheumatology Association, 2004 March; 12(1):6-10.
• Evolving role of Biological Response Modifiers in the management of Arthritis and Spondylitis. Author: Sundeep K Upadhyaya. Apollo Medicine, 2005 June; 2(2):107-110.
• Use of Anti-TNF alpha agents (Infliximab and Etanercept) in Rheumatoid Arthritis and Ankylosing Spondylitis: experience of a Rheumatology practice at Apollo Hospital, India.  Author: Sundeep K Upadhyaya. Apollo Medicine, 2005 June; 2(2):147-9.
• Management of Rheumatic Disease in Pregnant and nursing women. Author: Sundeep Kumar Upadhyaya. Apollo Medicine, 2006 March; 3(1):35-38.
• Limited Wegener’s Granulomatosis: an exception to the the Pulmonary- Renal syndrome; a systematic review of three cases and review of literature. Author: Sundeep Kumar Upadhyaya. Apollo Medicine 2006 September; 3(3):307-10.
• Immunotherapy for cancer with special reference to lung cancer. Author: Sundeep Kumar Upadhyaya. Apollo Medicine 2006 September; 3(3):277-84.
• Limited Wegener’s Granulomatosis: an exception to the “Pulmonary-Renal Syndrome”; a systematic review of three cases and review of literature. Author: Sundeep K Upadhyaya. Apollo Medicine September 2006;3(3):307-310.
• Lack of clinical association with antibodies to ribosomal P protein in Indian patients with Systemic Lupus Erythematosus. Authors: Vinod Chandran, Sundeep Kumar Upadhyaya, Nigil Haroon, Amita Aggarwal, Ramnath Misra. Journal of  Rheumatology, 2006 October; 33(10):1987-9
• Pulmonary hypertension in connective tissue disease. Authors: SK Upadhyaya, A Kumar.  Indian Journal of Rheumatology, 2007 September; 2(2):114-9.
• Musculoskeletal Disease in Primary Hyper-parathyroidism-Review of literature and Case report. Authors: Sundeep K Upadhyaya, NidhiMalhotra, Harsh Rastogi, Ambrish Mittal, Uma Ravishankar, CM Malhotra. Apollo Medicine March 2009;1(6):46-50.
• The management of neonatal lupus syndrome. Algorithms Author: Sundeep Kumar Upadhyaya. Apollo Medicine. Apollo Medicine September 2012;9(3):280-1.
• New and Emerging therapies for Rheumatoid Arthritis. Author: Sundeep K Upadhyaya. Apollo Medicine March 2009;1(6):51-54.
• The management of neonatal lupus syndrome. Algorithms. Author: Sundeep K Upadhyaya. Apollo Medicine. September 2012;3(9):280-281.
• Treatment of Early Rheumatoid Arthritis. Algorithms. Author: Sundeep Kumar Upadhyaya. Apollo Medicine. December 2012; 4(9):345-346.
• Treatment of Established Rheumatoid Arthritis. Algorithms. Author: Sundeep Kumar Upadhyaya. Apollo Medicine. December 2012;4(9):347-348
• The lung in Connective Tissue Disorders - A Hospital based prevalence study with clinical and Radiological Analysis of Cases – A Thesis by Dr. Shreeja Kumar. Guide – Dr. Sanjay Sobti, Co-guide- Dr. Sundeep Upadhyaya (In Press)
• Treatment of lupus nephritis in adult patients. Algorithms. Author Sundeep K Upadhyaya. Apollo Medicine. March 2013;1(10):85-86.
• Immunology of type-I diabetes: The journey from animal models to human therapeutics. Author: Sundeep K Upadhyaya. Apollo Medicine. June2013;2(10):105-107.
• Rheumatic manifestations in diabetes mellitus patients. Authors: Bhowmik Meghnathi, Sundeep K Upadhyaya. Apollo Medicine. June 2013;2(10):126-133.
• Antibodies to Tumor Necrosis Factors in the Treatment of Rheumatoid Arthritis and Spondyloarthritis: The Basic Science, Clinical Science and Unmet Needs; Results from a Single Center. Author: Sundeep K Upadhyaya. Open Journal of Rheumatology and Autoimmune Diseases, 2014, 4, 86-92. http://dx.doi.org/10.4236/ojra.2014.42013.

B. Clinical Research –

• Primary Investigator for Rheumatoid Arthritis
• for Jhonson & Jhonson Simponi ,phase IV trial - (RA)
• for Roche (ACT-SURE ) - (RA)
• for Elli Lily (BCDM, BCDO) - (RA)
• for Elli-Lily (BCDY) and JADZ,JADX,JADY- (RA)

C.Current Clinical-Research-

• To assess the construct validity of SDAI, CDAI, and HAQ-DI as compared to DAS        28 in patients with Rheumatoid Arthritis in an `Indian Tertiary Care Multi-Specialty Corporate Hospital in Outpatient setting. (Dr. Bhowmik Meghnathi DNB Thesis project: Chief Guide).
• To assess the efficacy and safety of a single intra-articular injection of High Molecular weight Hyaluronic Acid in patients with Osteoarthritis of the knee. (Dr Himanshu Aggarwal DNB thesis project:Co-Guide)
• Vitamin D Deficiency in Rheumatoid Arthritis: Prevalence and Impact on Disease Activity & Ability. (Dr. Bhupendra Vaishnav DNB Thesis project: Co-Guide)  
• D.Study of Serum TNFx, A.T.I. & Infliximaf concentration in patients with spondyloarthritis in treatment with Infliximaf (Dr. Abhishek Patil,DNB thesis project, Chief guide)